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Nevertheless, the existence of several TLS polymerases indicates that several alternative pathways may exist for copying the missing information during HR.
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Motivation: Several algorithms exist for detecting copy number variants (CNVs) from human exome sequencing read depth, but previous tools have not been well suited for large population studies on the order of tens or hundreds of thousands of exomes.
As these regularities in the methylation patterns at LINE-1 repeats have not been previously described, it has also not been investigated whether such patterns exist for single-copy sequences like CpG island gene promoters.
The fact that the TNT and RaxML trees are not completely congruent is not particularly surprising given that there are few parsimony informative characters in 16S rRNA and that there is no expectation that a tree-like branching pattern exist for these gene copies.
A variety of mechanisms exists for repairing copying errors caused by DNA damage.
To consider fully independent those families for which we have found only non-autonomous copies, we ought to hypothesize that hitherto undiscovered autonomous copies exist for those lineages.
No hard copies exist for a thief to steal.
Similarly highly degenerate pseudogene copies exist for other Grs, such as Gr27 and 47.
Assuming that around 1000 copies exist for each repeat other than Sm_alphafem, then this would correspond to around 10.5 Mb (~2.5% of the genome).
A similar situation exists for a copy number gain on chromosome 1q32 in18/24 tumors.
Several methods exist for collecting data, including hard copy questionnaires, on-line questionnaires (including text messaging), face-to-face interviews and telephone interviews.
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