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These data suggest that low- and high-Km pathways may exist for activation of NNK to a methylating agent.
Mei2 is a RNA-binding protein that is important for induction of meiosis in S. pombe (Sherwood and Bennett 2009), suggesting that a Mei2-indipendent pathway may exist for activation of meiosis in T. populina.
It is known that steroid-independent pathways exist for activation of a steroid receptor through signalling cascades from membrane-regulatory molecules, such as cAMP, dopamine, growth factors, cytokines, and possibly other cellular regulators acting at the membrane (Aronica and Katzenellenbogen, 1993; Ignar-Trowbridge et al, 1993; O'Malley, 2005).
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Support, although preliminary, exists for activation by Ca2+/CaM of the NADK2 isoform only.
It is important to note that while K13 is primarily responsible for constitutive NF-κB activation in PEL cells, additional mechanisms do exist for the activation of this pathway in KSHV-infected cells, including viral-encoded proteins capable of NF-κB activation, such as vGPCR and K1, both of which have been shown to block KSHV lytic replication [53], [54].
Homologues for IKK (Ird5 and Kenny) and TAK exist, and these have been shown to be required for activation of NF-κB/Relish following infection [ 19].
Furthermore, our observations that PhoQ activation by acidic pH and divalent cation limitation are separable from CAMP-mediated activation may indicate that distinct conformational states exist for each of the unique PhoQ-activating and -repressing stimuli.
Thus, it is possible that in Prph-ChR2 mice, an insufficient level of ChR2 for activation of LTMRs may exist.
This suggests that a similar mechanism of transcriptional regulation may exist for TUBB3 transcriptional activation as well as TUBB4, although a detailed analysis was not performed.
Twenty-eight nonsynonymous substitutions existed in transcriptional activation domains which were responsible for activation of CBF regulon genes.
Cleavage is usually needed for activation of the proteins, although exceptions exist in which cleavage results in inactivation, modified or even opposite activity.
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