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Also, persons from different regions where currently different pathways exist demonstrated different preferences.
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However, strong arguments exist demonstrating the limitation of control studies in complex educational settings (Berliner 2002; Maxwell 2004; Sadler et al. 2016).
Animal data exist demonstrating the efficacy of lipid emulsions in rodent and rabbit models of tricyclic antidepressant intoxication [3, 4], with early anecdotal human experience apparently supporting utility in desperate clinical circumstances [12, 13].
As indicated above, functional evidence exist demonstrating the importance of Nme gene for key biological processes, including development, cell proliferation, ciliary function, and cancer.
Several reports exist demonstrating that the degree of grape seed polyphenol oligomerization affects its biological activity to scavenge the reactive oxygen species [26], [27].
Some data exist demonstrating its efficacy in other oncologic indications.
Numerous examples exist demonstrating the ability of the kidney to cross-talk with other organs [ 41].
Although this implicates direct activation of neurons, little data exist demonstrating receptor-mediated neurotoxic actions of ET-1.
Renal replacement therapy has been used as therapy for AKI and data exist demonstrating that initiation prior to accumulation of excessive fluid overload may improve outcomes [ 23, 24].
However, the mode of action for BIT225 is unknown and no published data exist demonstrating its efficacy against HCV in culture.
However, more recent studies suggest that as many 12 molecular subgroups of ER + breast cancer exist, demonstrating that the luminal A and B stratification of ER + breast tumors does not fully capture the biological complexity of these tumors [ 5].
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