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This finding supports the hypothesis that low-abundance biomarkers circulating in blood may exist bound to albumin, preventing their clearance by the kidneys [ 12].
Mass spectroscopic analysis of human serum following molecular mass fractionation, demonstrated that the majority of LMM biomarkers exist bound to carrier proteins.
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It has been revealed that Sos1 can either exists bound to Grb2 or Eps8/E3b1.
In total, approximately 55% of selenium in human serum exists in selenoprotein P, another 17 32% exists bound to albumin, mostly in the form of selenomethionine, and only 10% of serum selenium is not protein bound [ 11, 18, 21].
It is thus likely that the cytosolic form of AMSH, and by extrapolation similar JAMM DUBs, would be bound to ubiquitin and exist in an inhibited state.
23 However, the situation is made more complex by the fact that GH also exists (reversibly) bound to GHBP, which is decreased in ESRD patients; the relative amounts of bound GH will most likely also correlate with the GH elimination rate.
Joseph Brodsky once wrote, "should the truth about the world exist, it's bound to be non-human".
Even the filibuster is pointless because procedures exist that were bound to force Cruz to yield the floor by Wednesday afternoon.
While bans exist propaganda is bound to have a distorted significance, but the thing that matters is that Soviet kinema, while being propagandist, contains a use of all the different branches of film-making which is recognised and practised in no other country.
To exist is to be inexorably bound to a past that is founded through intentional contact with the world.
Some hardware incompatibilities are bound to exist.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com