Exact(7)
It exhibits toxicity and causes disorders of the GLU and lipid metabolism.
Kan Wang et al. demonstrated the biocompatibility of GO, which exhibits toxicity to human fibroblast cells when the dose is less than 20 μg/ml but exhibits obvious cytotoxicity when dose is more than 50 μg/ml, with significantly decreasing cell adhesion [32].
SN-38G is excreted via the biliary track into the gut, where bacterial β-glucuronidases can re-activate the drug by converting SN-38G back to SN-38 (Stein et al., 2010), which exhibits toxicity toward intestinal epithelial cells and causes diarrhoea.
In comparison, the plant did not show any significant cytotoxic effects on normal human cells, while, the standard anticancer drugs (5'Fluorouracil and Doxorubicin) showed stronger cytotoxic effect than the Phyllanthus extracts, but exhibits toxicity on normal cells (Table 1).
The former experiments have been particularly informative, revealing important information regarding the concentration and biochemical form of extracellular Aβ that exhibits toxicity upon cultured neurons; from such studies it is proposed that soluble oligomeric forms of Aβ at >5 µM concentrations are the most toxic form of extracellular Aβ to neurons [3].
It is possible that mitragynine is relatively safe at lower subchronic dose but exhibits toxicity at a highest dose [ 20].
Similar(53)
Thiolated methylated arsenicals were shown to be more toxic than their oxygen-containing analogs and exhibited toxicity comparable to that of trivalent arsenicals [ 30, 36– 36].
However, the common chemotherapeutic cancer drugs, such as doxorubicin, exhibited toxicity and serious adverse effects [26].
Scientific studies have shown that synthetic compounds exhibit toxicity and carcinogenicity in the human body.
Local anesthetics and contrast agents have exhibited toxicity to cardiac, renal, and neuronal cells.
Natural or anthropogenic accumulation of heavy metals in the environment could be tenacious and exhibit toxicity towards living organisms.
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