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One reason for bimodal density functions could be a group of transcripts exhibiting higher variability compared to other transcripts.
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Briefly, we used genes exhibiting high variability across the infected macrophages and live, phagocytosed C. albicans at 2 and 4 h.
Deep Learning methods are powerful approaches towards this task as training with large amounts of data exhibiting high variability has been shown to significantly enhance their effectiveness, but often requires expensive computations and leads to models of high complexity.
Large-scale RNA-seq on single cells from breast cancer cell lines has shown that cells exhibiting high variability in RNA transcripts, which was also evident at the protein level, possess increased metastatic capacity and survival following chemotherapeutic treatment [42].
In addition they also identified 32 genera that are shared by all samples, exhibiting high variability in abundance across samples.
Three biomarkers (interferon gamma, tumour necrosis factor alpha, interleukin-10) were excluded from the analysis as they were exhibiting high variability between technical replicates.
It is also possible to contemplate incentives on area health services or hospitals in terms of prevention, particularly through discounted payments for admissions which might be better treated in a primary care setting and incentives for appropriateness of admission, through discounts for excess admissions in procedures exhibiting high variability.
In kayviruses, the homologs of the α-GlcNAc-binding RBPs exhibit higher variability than WTA-backbone-binding RBPs, which indicates that they determine the host specificity.
The test plants exhibited higher variability in yield than control ones.
The variability is compounded further by sample preservation e.g. formalin-fixed paraffin embedded (FFPE) exhibit higher variability than frozen samples.
Genes important for the majority of diagnostic datasets were highly ranked, while less importance was given to complementing transcripts, which exhibited higher variability (Fig. 3).
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