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This cancer is peculiar in its characteristics, exhibiting differentiation, maturation and metastatic transformation leading to poor prognosis and low survival rates among children.
Some eurypterids show an extraordinary degree of differentiation, with megalograptids exhibiting differentiation of every appendage pair (Fig. 26h), but the appendages of the basal-most eurypterids are either undifferentiated or exhibit differentiation of the posterior appendage pair only (Fig. 26g).
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Analyzing neuronal differentiation we demonstrated feeder-freed stem cells to exhibit differentiation potentials comparable to embryonic stem cells differentiated under standard conditions.
Here, we show that Lgl1 cKO cells fail to lose NG2 expression and exhibit differentiation defects.
In fact, chondrocytes exhibit differentiation plasticity and undergo phenotypic changes during the healing process.
Several species exhibited differentiation into body site-specific subspecies clades (Fig. 1c; Extended Data Fig. 2e u), defined here as discrete phylogenetically related clusters of strains, according to a silhouette-based score of niche association (Methods).
Volvox also exhibit differentiation between somatic (non-sex cells) and reproductive cells, a phenomenon considered by some biologists to be significant in tracing the evolution of higher animals from microorganisms.
Overall, the efficacy and side effect profiles of the two compounds exhibited differentiation at low to mid doses (0.03 0.1 mg ciclesonide, 0.01 0.03 mg fluticasone), while this differentiation diminished at the maximum efficacious dose (0.3 mg ciclesonide, 0.1 mg fluticasone), likely due to overdosing in this model.
Under differentiation conditions, the reprogrammed cells exhibited differentiation ability into neurons suggesting that, although fully reprogramming was not achieved, the cells could be transdifferentiated after reprogramming.
The derived cell line exhibited differentiation characteristics of urothelium including a polygonal, dome-shaped monolayer of cells with well-developed tight junctions and cytokeratin 18 expression.
Quantification revealed 34.4%±6.38 exhibited differentiation along the more immature Olig2-positive oligodendrocyte lineage and 13.8%±1.0 of human cells differentiated into mature APC-CC1 positive oligodendrocytes (Fig. 5).
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