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Following an initial attenuation, males, but not females, exhibited sensitization to nicotine's effects on spontaneous activity.
Dry skin mouse models exhibited sensitization to PAR2 agonists and a PAR2 antibody helped reduce scratching [ 125].
After 25 days of washout (on experimental day 38), animals re-challenged with 5.0 mg/kg exhibited sensitization across the HA, VA and NOS indices.
Indeed, LTD was normal in mice that did not exhibit sensitization following repeated ethanol injections, but decreased in magnitude in those animals that exhibited sensitization following the chronic drug exposure regimen.
In animals injected with 10.0 mg/kg MDMA, the initial high dose elicited a robust increase in locomotor activity, but only the HA and VA indices exhibited sensitization on experimental day 13 and again (25 days later) on experimental day 38.
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This is probably due to the potentially confounded nature of this paradigm, as drug is administered prior to the reinstatement session and due to the repeated nature of drug administration during the conditioning period animals may also exhibit sensitization during this test session.
LCL85 did not exhibit sensitization activity in Colon 26 cells to FasL-induced apoptosis in our initial attempts.
The two lines with moderate DCF-DA fluorescence exhibited IR sensitization upon PARP1 inhibition.
In line with this theory, R mice in this study should therefore have exhibited increased sensitization as compared to NR mice.
Enpp1−/− mice exhibited insulin sensitization and, in response to a chronic HFD challenge, displayed improved insulin tolerance and pronounced obesity resistance.
Withdrawal reflexes of the mollusk Aplysia exhibit sensitization, a simple form of long-term memory (LTM).
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