Sentence examples for exhibited poor solubility from inspiring English sources

As a BCS II drug, it has exhibited poor solubility and high permeability (Wu and Benet 2005).

This compound exhibited poor solubility and permeability, and presented a significant problem in the development of a successful dosage form.

Other deletion constructs (84 387, 84 413) without the N-terminal 83-aa domain showed high expression levels (Fig. S1B), but it exhibited poor solubility and stability (Fig. S1C), indicating that the completeness of BSE plays a significant role in maintaining the structure of the Mx2 constructs.

Similarly, the qCPT-Sup35 CAMs also exhibited poor solubility in pure MeCN, immediately forming huge precipitates with no well-defined structures observed by TEM.

However, in the course of working with these compounds in different buffered aqueous solutions, we observed that KYG-98, KYG-100, and KYG-101 exhibited poor solubility in some, particularly those with significant Zn2+ and Ca2+ levels that are used to assess enzyme activity, whereas KYG-97 and KYG-99 displayed excellent solubility in all of the buffers tested.

This trend is found for other polymers synthesized by us where the metallocene-containing polymers exhibit poor solubility in comparison to the analogous organotin polymers.17 The products are soluble in HMPA.

In contrast, hydrophobic solvents (e.g. heptane, hexane and toluene) exhibit poor solubility in water and compete much less for enzyme-bound water molecules.

Furthermore, these endoproteases are costly, often exhibit poor solubility, and require the inclusion of additional chromatography steps to remove the exogenous protease.

All compounds bearing a polar but nonionic substitution for the carboxylate of DD2 [compounds 4 7 (Table 1)] showed no inhibition of KSHV Pr, although some of these analogues exhibit poor solubility at low micromolar concentrations.

Although BCS class II drugs exhibit poor solubility, they can escape easily into the gastrointestinal tract (GIT), while dissolution rate defines the rate and degree of absorption of class II drugs.

Because PEG conjugates with more than 4 Ret-NH2 molecules per polymer chain exhibited poor water solubility, the conjugate with four molecules of Ret-NH2 on average with a water solubility of 30 mg/mL at room temperature was selected for in vivo experiments.