In particular, we show that a critical window for the interaction of pre- and postsynaptic spikes emerges as an ensemble property of the collective system, with individual synapses exhibiting only a minimal form of spike coincidence detection.
Although the two fCJD cases had an identical PRNP, one with a 4-year course exhibited only minimal focal spongiform degeneration and another with a 10-year course showed significant astrocytosis, neuronal loss and pronounced spongiform degeneration [ 25].
The promoter mutant −214/−50, in which the transcription start site had been lost, exhibited only minimal transcriptional activity and was used as a negative control.
Despite its potent activity in the induction of intraabdominal abscesses [12], purified CP8 exhibited only minimal potency in the s.c. abscess model, even at a 50 µg dose.
The compound also exhibited only minimal effects on in vivo NAD levels in mice, and these changes were considerably less profound than those produced by an imidazo-pyridine-containing NAMPT inhibitor.
At later stages, larvae injected with krt5:edn3 transgene exhibited only minimal rescue phenotypes (Supplementary Fig. S2C); indeed, krt5 Edn3 expression could not be detected post-embryonically (not shown), presumably because transgenic cells in the mosaic yet proliferative epidermal environment had been depleted, or because the transgene itself had been silenced.
GR85 and BB82 (Xand6-1 and 2) exhibited distinct staining patterns with GR85 showing some cytoplasmic and peripheral nuclear staining not seen in its BB-immunized BB82; littermates GR80 and CF5 (XA345-1 and -2) both exhibited only minimal ANA staining although CF5 that produced some anti-dsDNA after the fifth boost also developed increased ANA fluorescence with some nucleolar staining.
Similarly, shASNS-infected cells exhibited only minimal OP-puromycin staining, while synthesis of new polypeptides was restored in shASNS-infected sarcoma cells grown in medium supplemented with asparagine.
Specifically, in transactivation assays TA 1-10) was at least as active as native TAp63γ, while both ΔN(3′-10) and ΔNp63γ exhibited only minimal transactivation.
An abdominal MRI performed 9 months after the initiation of corticosteroid therapy exhibited only minimal cortical defects in both kidneys whereas the lesions located in the medulla had receded.
