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The Y204F FPPS mutant exhibited no alteration in Ki for ZOL with respect to the wtFPPS (Table 3).
exhibited no alteration of SLA, but a reduction in Gs alongside an increase in Gm with elevation that corresponded to enhanced Vcmax (Shi et al. 2006).
As shown in Figure 6a and Supplementary Figure S6, phosphorylation of p38 (T180/182) was indeed increased with PL treatment, which could be blocked with NAC, whereas phospho-p44/42 phospho-p44/42r of the mitogen-anothered protein kinase (memberfamily exhibited nofaltheation, suggesting that PL specifically induces activation of the p38 pathway.
Given that this mutant cell line, like the others tested here, exhibited no alteration in its ability to form damage-induced Rad51 foci, this raised the possibility that the T3232A mutation might promote the persistence of Rad51 foci after their formation.
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RESULTS:Whereas tamoxifen-treated HSA-Cre mice fed a low-fat diet exhibited no alterations in glucose homeostasis, we observed marked improvements in glucose tolerance in tamoxifen-treated, but not corn-oil-treated, HSA-Cre mice fed a high-fat diet vs their wild-type littermates.
The animals that were treated only with either dose of MH exhibited no alterations in TBARS levels (data not shown).
Male mice, following 14 or 90 days of exposure to 1/10 and 1/100 the actual oral LD50, exhibited no alterations in either humoral or cell-mediated immunity.
We report here that the best known transcription factor associated with sepsis, NF-κB, exhibits no alteration in transcript quantity.
Interestingly, Cheng and colleagues [ 42] reported that mPGES-1-null mice exhibit no alteration in thrombogenesis or blood pressure, whereas selective COX-2 inhibitors (Coxib) did.
Survival analyses did not identify any statistically-significant associations between disease-free survival time in patients with tumours exhibiting alterations in expression of these genes as compared with patients with tumours exhibiting no alterations in expression (p > 0.05) (data not shown).
These plants exhibited no obvious alteration in plant growth or morphology (not shown), and no alterations in vascular organisation or cell number were observed (Figs 6, 7).
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