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But high-placed Israeli intelligence officials exhibited heightened N.F.C., and they froze on the early conventional wisdom — that the chances of an attack were quite low — and failed to adequately incorporate new signals, blocking off conflicting information as to the attack's imminence.
Except for decorin, which exhibited heightened mRNA levels even in the early stages of osteogenesis, we found similar upregulated mRNA contents (up to 14.6-fold) for all investigated PG core proteins.
In response to a pharmacological ER-stress agent, eIF2B5 R195H) expressing cells exhibited heightened ER-stress response demonstrated by hyper induction of ATF4, GADD34, Bip, PDIA1, PDIA3, PDIA4 and PDIA6 proteins.
Chaetocin-treated tumors exhibited heightened ROS, pATM, YAP1 and pJNK levels.
While both AMD and 5-1 were able to adhere to the ME-180 monolayer, AMD exhibited heightened adherence.
LRP5-KD gluteal adipocytes further exhibited heightened inflammation as determined by increased IL6 and MCP1 transcript levels.
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Our results add to the accumulating literature investigating the adaptive rationale for exhibiting heightened fear responses when viewing trypophobic imagery.
However, no study to date has directly examined whether current problematic drinkers exhibit heightened reactivity to uncertain threat as would be expected.
An emerging hypothesis is that individuals who exhibit heightened reactivity to uncertain threat may be especially motivated to use alcohol to dampen their distress, setting the stage for negative reinforcement processes to drive excessive alcohol use.
It is interesting that this upregulation is specific to skeletal muscle, which exhibits heightened oxidative stress in the G93A mouse [32], and also presents with a reduction in ATP levels through a decrease in the mitochondrial respiratory control ratio [54].
We hypothesized therefore that the neutrophils, monocytes and dendritic cells in the lamina propria of FMF patients may exhibit heightened sensitivity to the physiologically normal concentrations of bacterial ligands entering from the gut lumen and may provoke the episodes of acute inflammation as well as contribute to the chronic subclinical inflammation in remission.
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