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Moreover, scaffolds reinforced with up to 60 vol% HA exhibited fully recoverable elastic deformation upon loading to 50% compressive strain for at least 100,000 cycles.

Although numerous species, such as australopithecines and early hominids, have exhibited fully bipedal locomotion, humans are the only extant species with this trait.

Importantly, WT-FIH exhibited fully coupled turnover, such that O2 activation always led to substrate hydroxylation.

Wash-out of drugs was performed by re-perfusion of the 10 mM Ca2+ containing extracellular solution onto STIM1/Orai expressing HEK293 cells that exhibited fully blocked Orai1/Orai3 currents.

The Grhl3 cre-nZ/cre-nZ; β-catenin +/ − embryos exhibited fully penetrant spina bifida, similar to Grhl3 cre-nZ/cre-nZ alone, but more than half of the embryos displayed exencephaly (55.0%) (Fig. 8A, B″, C″).

In contrast, mice with germline KO of Esrp1 exhibited fully penetrant bilateral cleft lip and cleft palate (CL/P), and these mice are neonatal lethal on post natal day 0 (P0) most likely due to orofacial clefting.

Operating in a strictly periodic fashion, the platform exhibits fully predictable real time behaviour.

In this respect, concerning the compounds which exhibit fully amorphous structures a better understanding of their structural behavior can be obtained in the framework of Flory's theory of semi-rigid polymers.

In agreement with this hypothesis, MBD2 depletion did not induce pS2 transcription in MDA MB231 cells exhibiting fully methylated pS2 5' end.

Further support for a role of the PI3K/Akt signaling pathway in this context is contributed by our observations that all IGF-1R constructs exhibiting fully detectable Akt phosphorylation are mainly degraded by the lysosomes.

Embryos expressing only CYK-4EE, like those expressing CYK-4R459A and CYK-4∆C1, exhibit fully penetrant embryonic lethality.