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−31, −10 and −7 exhibited enhancer activity in both K562 and HPB-ALL, while +51 was only active in K562, suggesting it had erythroid-specific enhancer activity.
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Role of Tet proteins in enhancer activity and telomere elongation.
Brunelle, M. et al. The histone variant H2A.Z is an important regulator of enhancer activity.
a) Domain-wide impact of Rad21 deletion on enhancer activity and gene expression.
Nevertheless, the potential role of DNA methylation in regulating enhancer activity during reprogramming remains uninvestigated.
Wiench, M. et al. DNA methylation status predicts cell type-specific enhancer activity.
Therefore, inhibition of cancer-specific enhancer activity is a current direction in anti-cancer drug development15,16,17.
The enhancer activity is due to a cooperative and synergistic interplay of different coactivators and TFs57.
Raisner, R. et al. Enhancer activity requires CBP/P300 bromodomain-dependent histone H3K27 acetylation.
Reilly, S. K. et al. Evolutionary changes in promoter and enhancer activity during human corticogenesis.
Troelsen JT et al: An upstream polymorphism associated with lactase persistence has increased enhancer activity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com