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A quality assurance professional with an analytical chemistry background might be challenged by the reality that medium formulations do not exhibit potency analogous to a pharmaceutical agent.
These compounds are synthetic small molecules derived from LBA that exhibit potency in the nanomolar range.
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Most of the target compounds exhibited potency levels in the nanomolar range.
Most of the compounds exhibited potency levels in the micromolar/submicromolar range.
Surfactants with smaller silicone head groups had as much as 4 times the bioactivity of surfactants with larger groups, with the smallest hydrophobe exhibiting potency equivalent to sodium dodecyl sulfate (SDS).
X-ray crystallography illuminated the S1′ residues critical to this effort, which culminated in compounds 56 and 57 that exhibited potency and selectivity but poor permeability and high P-gp efflux.
Thus, landiolol hydrochloride exhibits potency similar to that of esmolol hydrochloride, and has improved safety characteristics.
Interestingly, KL034, which has a methoxyethyl group, exhibited potency similar to that of KL001.
Notably, the N-terminal half of THOC5 exhibits potency of the complex formation with its target mRNAs.
Therefore, OML uptake can induce activation, differentiation, and maturation of APCs, and thus OML itself exhibits potency as an adjuvant.
Among the small-molecule antagonists of antiapoptotic BCL-2 family proteins, GX15-070 (obatoclax), which is an indole bipyrrole compound, exhibits potency against MCL-1.
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