When the feeling is absent, he exhibits irritation, rage, or most unsettlingly an unhappiness that threatens to spiral into despair.
When the feeling is absent, he exhibits irritation, rage, or — most unsettlingly — an unhappiness that threatens to spiral into despair.
The researchers reported that other chewers, frequently those not found to have cancer, exhibited irritation of the gums as well as mouth lesions, known as leukoplakia, that can be precancerous.
They exhibited irritation regarding the conflict between their perception of their deteriorating physical condition and the unclear information they had been given.
Basil oil cream formulations exhibited barely perceptible irritation hence considered being non-irritant to skin at the applied dose (500 mg).
Topical application of bee venom can be well tolerated in the human skin, because it has exhibited no dermal irritation potential in animal studies.
It was observed that optimized formulation showed better ocular hypotensive activity and also exhibited no ocular irritation effects observed in the rabbit eye.
Mucoadhesive (carbopol 940) coated nanovesicular system of brimonidine tartrate have been found to provide better ocular hypotensive activity than marketed drops on albino rabbits and exhibited no ocular irritation effects [ 64].
In vivo studies indicated that Span 60 based niosomes were shown to improve the ocular bioavailability of diclofenac sodium for the prolonged period of time and exhibited no ocular irritation effects.
Maiti et al. [ 64] studied the stability of nonionic surfactant based nanovesicular formulation of brimonidine tartrate and observed that the formulation when stored at refrigerated temperature offered maximum physical stability and also exhibited no ocular irritation.
