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Affected individuals exhibit heart abnormalities (which may cause early death), extra digits, defective dentition, poorly formed nails, dwarfing, and often knock-knees and fusion of hand bones.
The cardiac expression of FMR4 may possibly be of functional relevance considering the fact that many patients with fragile X syndrome exhibit heart defects such as dilation of the aortic root and mitral valve prolapse [24], [28].
It is interesting that knockout mice for each sirtuin isotype exhibit heart abnormalities, while transgenic overexpression of all three provides protection from cardiac hypertrophy.
A number of Hsa21 trisomy mouse models exhibit heart defects similar to those observed in DS, suggesting that trisomy of one or more of the approximately 100 genes common to these models influences development of the heart (22, 26, 103, 104).
Because patients with juvenile polyposis syndrome and chromosome 10q23 deletion syndrome exhibit heart defects (Delnatte et al., 2006; Menko et al., 2008; Zhou et al., 2001), we assessed heart morphology in double-tg at birth by micro-CT and histomorphological analyses.
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In fact, even from a very young age, Crystal showed me she was a special person, always exhibiting heart and wisdom well beyond her days in this world.
At 3dpf, for example, they exhibited heart edemas and an inflated yolk sac (Fig. 6B).
Ayaz et al. [ 5] reported that Sel treatment may prevent and alleviate the symptoms of diabetes in animal models exhibiting heart, kidney, and platelet defects.
Again, a statistically significant number of Tc1 samples exhibited heart defects at E18.5 (21%, n = 33; Table 1 ) compared with wild-type littermates.
Further, no dissected AD or AR animals exhibited hearts of unusual size or shape compared to controls.
A book of essays on the organ's cultural importance accompanies the exhibit ("The Heart" edited by James Peto, Yale University Press).The permanent exhibitions contain quite a few human specimens.
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