A great advocate for the fiction of her rivals, she waxes lyrical about Hilary Mantel's Booker-tipped Wolf Hall, a book that says far more about Henry VIII's life, she claims, than "that ridiculous David Starkey exhibit down at the British Library".
Plasmon resonances are widely used in biomolecular sensing and continue to be an active research field due to the rich variety of surface and measurement configurations, some of which exhibit down to single molecule level sensitivity.
Ovaries of TBP2 knockout mice exhibit down regulation of genes involved in chromatin organization including oocyte-specific linker histone H1, H1foo, and the DNA methyltransferase Dnmt1 [ 57].
On the other hand, we have observed that fibroblasts isolated from the dermis of old human donors exhibit down regulation of a gene cluster associated with gene ontology terms of nucleosome assembly, telomere packaging, chromosome maintenance and the mitotic cell cycle as a major systematic alteration [ 20].
Fired from specifically designed air rifles, gel-loaded biobullets exhibit down-range ballistic properties (i.e., kinetic energy, trajectory, accuracy) similar to unloaded biobullets.
These results showed that FMNPs can induce adhesion-associated proteins exhibit down-regulation expression, leading to thinning of cell basement membrane and decrease of the cell adhesion ability, finally resulting in cellular apoptosis or death.
Again, four genes (OsARM46, OsPUB21, OsPUB75, and OsARM87) were found to exhibit down-regulation together under drought and salt stress.
Recently, Wu et al. [ 60] showed that Arid4a-deficient mice exhibit down-regulation of several homeobox genes and of the forkhead box gene Foxp3, which codes a transcription factor involved in the development and function of regulatory T cells [ 61].
As such, multiple human breast tumor cell lines exhibit down-regulation of connexin gene expression [ 230], and deficiency of Cx43 gap junctions is considered as a marker of breast tumors [ 231].
Many mutants that exhibit down-regulation of the Shh pathway show impaired Gli3 processing, with a decrease in the amount of Gli3 repressor relative to the amount of full-length Gli3 protein, as seen in mutants for Dync2h1/Dnchc2, IFT88/polaris, IFT172/wimple, Kif3a, Rpgrip1l/fantom and the chicken talpid mutant (38, 67– 69, 72, 73, 112).
It is known that cancer cells frequently exhibit down-regulation of gap junction proteins [ 52], and chemopreventative treatments to increase connexins offer improved anticancer activity; thus, viewed from the up-regulation of connexin genes, LH may exhibit a moderate negative effect on cancer growth and migratory properties.
