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In particular, sos1 plants were demonstrated to exhibit deficiency in the high-affinity K+ uptake in roots, which suggested a primary role of the SOS1 locus in mediating high-affinity K+ absorption into roots (Wu et al. [1996]).
We also demonstrate that PD patients without GBA mutations exhibit deficiency of GCase in SN.
Aged mice also fail to mobilize intracellular fuel reserves from brown adipocytes and exhibit deficiency in homeothermy.
Thereafter, some mice started to exhibit deficiency symptoms (malaise, lethargy, and weight loss), at which point experiments were terminated.
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Commercially available skin substitutes have improved HTS outcomes but exhibit deficiencies with revascularization/reinnervation, pigmentation, and adnexal structure formation.
Cells depleted of Grx3/4 exhibit deficiencies in RNR nucleotide reduction activity, but the mechanism remains to be elucidated (Zhang et al., 2008; Li et al., 2009; Netz et al., 2010, Ueta et al., 2012).
Since c-Rel expression is restricted to mature hematopoietic cells, c-Rel knockout exhibit deficiencies only in the immune response to antigens [8], [48] [51].
Since AKAP5 is most highly expressed in the ventral and dorsal striatum where it colocalizes with RIIβ [6] we tested whether AKAP5 mice would exhibit deficiencies similar to those seen in RIIβ KO mice.
While the receptor for this chemokine is unknown, it is broadly expressed in adult tissues (breast, kidney) and has been reported to be a chemoattractant for dendritic cells and monocytes [58], [59], although mice lacking this chemokine do not exhibit deficiencies in dendritic cell trafficking [60].
IRFKO and CSFRKO mice both exhibit deficiencies in the frequency of LCs [ 34, 40].
However, our results indicate that the satellite cells in mdx mice still exhibit deficiencies in self-renewal capability.
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