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Our data exhibit concordance with findings of Medina et al.
Isolates from infected PACs were most likely to exhibit concordance with concomitantly infected introducers (71%).
About half of the genes regulated by long-term oestrogen and not regulated by EGF exhibit concordance with ER status, whereas most of the genes regulated similarly by both treatments show a discordant relation with ER expression (Fig. 1).
These mathematical models suggest that MC-MZ twins, who have virtually identical intrauterine environments in addition to genetic likeness, would have concordance rates at about 95 100%, while DC-MZ twins would exhibit concordance rates comparable to DZ twins or ordinary nontwin siblings.
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Interestingly, copper overload exhibited concordance in the requirement of several genes associated with intracellular trafficking (for example, VPS27 and VPS21) and iron transport (FTR1), suggesting that excess copper (in addition to its deficiency) alters iron homeostasis.
Eighty per cent of infected PACs (the introducer or PAC) exhibited concordance with organisms cultured from skin of the insertion site, 17% with a contaminated hub, and 18% with organisms contaminating the extravascular PAC portion beneath the sleeve.
Then Harrell's C-statistic is the proportion of informative pairs exhibiting concordance between their prediction scores (h i, h j) and their observed survival times (T i, T j), where concordance is defined as the case wherein the individual with the higher (worse) score has the shorter survival time, and vice versa.
By applying WES, we find that CTCs and cfDNA exhibit high concordance in exome-wide SSNVs and SCNAs and uncover the majority of SSNVs and SCNAs present in the tumor biopsy.
We find that cfDNA and CTCs exhibit high concordance of SSNVs and SCNAs, reflect the clonal composition of the matched tumor biopsy, and uncover additional mutations exclusive to either CTCs or cfDNA, allowing blood-based tumor profiling in a greater fraction of patients.
Thus, a disease caused solely or partly by faulty genes will exhibit higher concordance among monozygotic than dizygotic twins; for diseases caused by environmental factors (such as smoking, workplace exposure, or viral infections), concordance will be lower, and almost equal in both kinds of twins.
Phylogenetic trees constructed by the minimum evolution (data not shown) or neighbor joining (Figure S4) methods also exhibit high concordance with the CCs generated via goeBURST.
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