Exact(3)
Ctf18 physically associates with Ctf7 in vitro and both ctf18 yeast mutant cells and human cells reduced in Ctf18 levels exhibit cohesion defects [23], [30], [31], [34].
A fourth prediction of the hypothesis that Rad61 and Elg1-RFC regulate cohesion through a singular mechanism is that rad61 elg1 double mutant cells should exhibit cohesion defects identical to either single mutant strain.
This model is based on findings that CTF18 deletion is lethal in combination with mutations in either CTF7ECO1 or MCD1 sister chromatid cohesion genes and that ctf18 mutant cells exhibit cohesion defects.
Similar(57)
Our results demonstrate that Elg1p exhibits cohesion activities and that this activity is distinct from that exhibited by Ctf18p.
After one day of treatment, bleb- cell sheets exhibited cohesion strength comparable to that of control cells, which themselves exhibited increased cohesion (compared to controls at day 0).
In the current study, we evaluated a panel of five commonly employed aneuploid HL cell lines and show that each exhibits cohesion defects ranging from 10.2%to55.4%4%.
Only 12% of pachytene nuclei exhibited cohesion in SCC-1-depleted kleisin triple mutants, indicating that SCC-1 cohesin can mediate REC-8 and COH-3/4-independent linkages.
We then determined that each Hodgkin lymphoma cell line exhibited cohesion defects that were subsequently classified into mild, moderate or severe categories.
Consistent with predictions, the narratives in schizophrenia exhibited less cohesion even after controlling for age and education.
Every atom in the superfluid is in the same quantum state, exhibiting a cohesion that's mathematically similar to a starling flock.
Using the Aureli et al. [71] description of fission-fusion dynamics and data from Campbell et al. [55], species exhibiting variable cohesion and party size (including multilevel societies) groups were classified as fission-fusion.
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