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In addition, only aortic arch 1 (AA1) is fully formed in the morphants, while AAs 3 through 6 do not exhibit circulation (Figure 3E,F).
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Our results demonstrate that formulations prepared with 50 mol% DODAC or DC-CHOL, and 20 mol% DSPE-PEG2000 exhibited circulation half-lives ranging from 6.5 to 12.5 h.
Rod- and disc-shaped particles exhibit enhanced circulation and targeting to cancer and inflamed endothelium.
Hence, results substantiate the application of adsorption isotherms for designing nanoparticles possessing potential to exhibit prolonged circulation when administered in vivo.
Samir's technical contributions are in the area of drug delivery and include the development of unique bio-inspired nanoparticles with engineered shapes and mechanical properties that exhibit enhanced circulation and targeting to cancer and inflamed endothelium.
In this study we wanted to determine whether highly charged cationic liposomes with surface-associated PEG could be designed to exhibit extended circulation lifetimes, while retaining tumor vascular targeting properties in an HT29 colorectal cancer xenograft model.
For example, RBC-mimetic synthetic particles have been developed that mimic the shape and mechanical properties of RBCs to exhibit prolonged circulation.
It has been noted previously that vesicles with a mean diameter of 100 nm exhibit longer circulation times than smaller or larger vesicles with the same composition [ 17].
To create a nanoplatform that could simultaneously exhibit long circulation times, achieve appreciable tumor accumulation, generate computed tomography (CT) image contrast, and serve as a radiosensitizer, gold-loaded polymeric micelles (GPMs) were prepared.
The electrochemical tests indicate that the LiAlO2/C composite exhibits outstanding circulation property at a current density of 0.1C and excellent rate performance.
3,4-Difluorobenzylidene curcumin (CDF) is a nontoxic analog of curcumin (CMN) developed in our laboratory, which exhibits extended circulation half-life, while maintaining high anticancer activity and improved pancreas specific accumulation in vivo, compared with CMN.
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