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Mammary and kidney epithelial cells exhibit a switch between TGFβ-induced TGFβ-inducedd EMT when cultured on compliapoptosisgid substrand, rEMTectively [99].
Tumor cells undergoing mesenchymal-to-epithelial transition (MET) have been reported to exhibit a switch from a spindle-like to a round morphology and to have reduced metastatic capacity.
Both PPARδ and PGC-1α transgenic mice exhibit a switch from reductive to oxidative fibers, and muscle-specific ablation of PGC-1α leads to reduced expression of MyHC I and IIA in oxidative fibers and impaired exercise capacity (Handschin et al., 2007).
Furthermore, cell lines derived from bladder cancers of lower stage and grade expressed FGFR3 IIIb as their major transcript, while cells derived from high grade tumors exhibit a switch to favour FGFR3 IIIc expression, suggesting that FGFR3 IIIb may have tumor-restrictive properties in bladder cancer [ 157].
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The memory elements exhibit a switching coefficient of ∼104 and a minimal programming time of 0.5 1.5 ms.
Many applications in chemical engineering often exhibit a switching character due to the presence of discrete modes in the course of their operation.
Birds preying on budworms were assumed to exhibit a switching functional response [3], searching for other food resources when the population of budworm is low, and switching to budworm only when the density of budworm exceeds a certain threshold.
Furthermore, we clearly demonstrated that NFATc1/A induction does not exhibit a switch-like dependence on calcineurin/NFATc2 activity.
First, it has been observed that many genes exhibit a switch-like ON/OFF activity in terms of their expression [ 4].
Experimental observations suggest that protein levels within cells may exhibit a switch-like 'all' or 'nothing'ON'or'OFF 'OFF') response - for example, p53 response to DNA damage [ 26, 27], TNFα stimulation [ 28, 29], MAPK signaling events [ 30], and drug treatment [ 31].
Therefore, we conducted a formal overlap analysis to investigate the degree to which specific regions exhibited a switch from one control mode to another depending upon interference expectancy (Figure 1).
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