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Similarly, preadipocytes from IRS1 KO mice exhibit a marked decrease in differentiation and lipid accumulation [20], [23], [42].
As shown in Figure 6, rats injected with shamporter + nephrin siRNA exhibit a marked decrease in nephrin specific staining, compared with animals injected with control siRNA.
Comparison of 2D gels revealed that in the absence of inflammatory stimulus CF cells exhibit a marked decrease in the expression of TRX-1, PRDX-1 and 6, catalase and GST-pi, but a marked increase in SOD2 compared with normal matched cell pairs (Table 1).
Second, ARDS patients exhibit a marked decrease in lung and sometimes chest wall compliance [ 5].
In humans, most tissues exhibit a marked decrease in telomere reserve over time [ 1, 2].
Additionally, Lindberg showed recently that mutant mice lacking the PBGD gene exhibit a marked decrease in large-caliber axons and manifest general motor neuropathy (Lindberg et al, 1999).
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Conversely, estrogen receptor beta (ESR2), G-protein coupled receptor 85 (SREB2) and the mesothelial fibroblast growth factor 9 (FGF9) exhibited a marked decrease of BRCA1 binding upon protein methylation inhibition.
Our data (Figure 5) show that mitochondrial cytochrome c content was maintained with ACET treatment, whereas P2VEH rats exhibited a marked decrease in cytochrome c content.
The population of BAR-T cells infected with pSuper-p53RNAi exhibited a marked decrease in baseline p53 expression, with a selected clone showing complete elimination of baseline p53 expression (Figure 1A).
As demonstrated in Fig. 8B, cells transfected with active heparanase exhibited a marked decrease in expression of MMP-2 (5.8 fold), MMP-9 (6.5 fold) and MMP-14 (3 fold), a mirror image of the increased expression found in Hpse-KO mice.
We observed that after treating cells for 48 h with the SCD1 inhibitor, cancer cells exhibited a marked decrease in the content of both cyclin D1 and CDK6 (Fig. 1B).
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