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Yap deficient mice exhibit a dramatic reduction of crypt proliferation, and the ISCs marker Olfm4 is strongly downregulated.
Purified mutant proteins exhibit a dramatic reduction in NIR activity while retaining BER functions and the ability to reduce sensitivity to alkylation DNA damage when expressed in E. coli.
Additionally, prion-infected mice exhibit a dramatic reduction in endogenous Sho protein.
Relative to most other vertebrates (Li and Zhang 2014), bird species exhibit a dramatic reduction in the Tas2r repertoire size.
Here we have identified that early diverged and basal genera ('leaf mimic' chameleons; Palleon, Brookesia, Rieppeleon and Rhampholeon) exhibit a dramatic reduction of independent carpal and tarsal elements in adults despite maintaining a normal pentadactyl number of digits and phalanges.
As a population, non biology majors did, however, exhibit a dramatic reduction by 24.6% in the proportion of surface feature card pairings they constructed, with a larger increase in the proportion of unexpected card pairings (14.2% increase) compared with the increase in deep feature card pairings (10.4% increase; Figure 4 and Table 2).
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In a simulated air environment, Li-air battery with the CNTs@CoO/Co electrocatalyst exhibits a dramatic reduction of charge voltage overpotentials (0.39 V) and good cycling stability (110 cycles) as compared with that made with bare CNTs.
Compared to a pure Ni-P coating, the Ni-P-MoS2 composite coating exhibited a dramatic reduction in friction coefficient against a bearing steel ball from 0.45 to 0.05.
We found that human telomerase reconstituted with hTERT Q169A, Q169D, or Q169N exhibited a dramatic reduction in catalytic activity compared to the WT enzyme (Figure 2A).
Furthermore, Dicer-deficient mice exhibited a dramatic reduction in blood pressure due to significant loss of vascular contractile function and SMC contractile differentiation as well as vascular remodeling.
Finally, we discovered TNFα as an essential mediator of dsDNA-induced acute inflammation, as mice lacking the TNF receptor exhibited a dramatic reduction in the inflammatory response to dsDNA stimulation in vivo.
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