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Rather than becoming exhausted upon engagement of PD-L1+ tumors, we hypothesized that CD8+ cytotoxic T lymphocytes (CTL) genetically modified to express this PD1 CD28 chimera would exhibit enhanced functional attributes.
This indicated that NK cells preactivated with IL-12/15/18 do not become exhausted upon adoptive transfer.
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Europe is the policeman in Austria who welcomes exhausted refugees upon crossing the border.
Such was the fate of the exhausted traveller upon reaching the famous John O'Groats back in the day.
For example, a patient dialysing through a complex upper limb graft may have no lower limb options due to arterial disease and thus could progress from Group 1 to Group 3 exhausted VA upon loss of graft patency.
You can't be telling exhausted, depressed, put-upon police officers to dry their eyes or quit.
Holidays are a concentrated chance to ogle other clans' frictions and fissures, whether with pity or silent relief: bawling infants; teenagers sullenly trailing their elders; slacking fathers and exhausted mothers; put-upon grandparents.
If he's already exhausted and feeling put-upon at the office, starting a fight about his work hours is the wrong tack to take, said Meyers.
The tide now turned, and the Western Allies launched a series of successful attacks upon the exhausted Germans.
She loses one but retrieves it, only to notice, upon returning exhausted at the end of the afternoon to the door of Hamilton, the gamekeeper, that she is again missing a dog.
One of the best pieces is "A Dream of Fair Waters", which describes a group of exhausted wanderers who stumble upon a mirage, an ocean of light: The shore shelved until our heads bobbed blueness – should we go on?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com