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T cells that escaped apoptosis rapidly became exhausted, memory formation was poor, and therapeutic impact was minimal.
dUnlike the exhausted memory cells in HIV-infected and malaria-infected subjects, double-negative cells in SLE do not express FCRL4.
Immunosenescence is characterized by dwindling production of naïve lymphocytes due to myeloid skewing and thymic degeneration, by increasing representation of functionally and proliferatively exhausted memory cells, and by deficiencies in innate immune mechanisms [ 8– 10].
The IgD−CD27− B-cell population, which has been described as comprising exhausted memory B cells (19), was also decreased from 7.9 ± 6.9% preinduction to 1.9 ± 1.2% at 6 months (p < 0.01), remaining low up to 12 months (2.3 ± 1.4%, p < 0.05, Figure 2C).
This finding may be explained by the recent report that HIV-specific B cells are present within a population of "exhausted" memory B cells, characterized by the expression of inhibitory receptors and low levels of CD21 [57], [57].
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Note that this value is decreased for even larger number of particles to avoid exhausting memory.
It's filled with the constraining power of the past of family tribulations, local traditions, exhausting memories of pain, and blindly borne and unexamined identities and the frozen resignation and benumbed passivity that it instills like an inner permafrost.
Since with this encoding only a few features would be non-zero, we tried to implement the encoding with a sparse matrix, but the dimensions involved (billions of records by billions of features) showed to be too large also for this kind of representation, and our attempts exhausted the memory available to our testbed.
While these cells could represent those that develop into strong effectors as demonstrated in Mycobacterium infection [65], they could also comprise an accumulating but exhausted CD8+ memory cell population with diminished Ag-responsiveness, found more commonly in older individuals [66].
The phrap program could not successfully process large datasets, even under its manyreads option, because it exhausted system memory.
While Boston began mentally preparing itself for the inevitability of having to win in overtime, Chicago, perhaps already exhausted by memories of their triple overtime win over Boston earlier in the series, made those preparations unnecessary.
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