He was her fifth child, she said, with an exhausted expression that revealed neither happiness nor sorrow.
It's cold, and she wears the same exhausted expression as the other villagers when I ask her what's been happening.
It's cold, and she wears that same exhausted expression as the other villagers when I ask her what's been happening.
One result comes clear in the views of a street vendor and the rancorous, edgy or just plain exhausted expressions of others across the capital.
NK cells activated with IL-2 in vitro do suppress acute GvHD upon adoptive transfer [ 5], however they also become exhausted and lose expression of Eomesodermin (Eomes) and T-bet [ 14].
One might try to replace (i) with a stronger claim, for example, that the use of an expression is exhausted by its employment in asserting, asking, commanding, and a few of other speech acts not including referring.
The conflict is supposed to arise because (i) the use of an expression is exhausted by its employment in speech acts, and (ii) it is sentences, not words, that can be employed to make speech acts.
Since the likes of James Turrell, Doug Wheeler, and others, conceptualizations of space with light remain an ever-popular (and perhaps slightly exhausted) medium of artistic expression.
DOI: http://dx.doi.org/10.7554/eLife.03416.020 Stable PD-1 expression in exhausted CD8+ T cells is associated with DNA demethylation within the CR-B and CR-C regions of the Pdcd1 promoter (Youngblood et al., 2011).
Recent efforts have proposed that specific transcription factors such as T-bet were associated with T-cell exhaustion, which were supported by the evidence that T-bet directly repressed transcription of the gene encoding PD-1, and high T-bet expression sustained exhausted CD8+ T cells in mice infected with LCMV, reminiscent of its role in sustaining exhausted CD4+ T cells.
The evidences provided by these articles not only showed the reduced effector functions and elevated PD-1 expression on exhausted CD8+ T cells but also verified the blockade of the PD-1/PD-L1 pathway could result in increased proliferation and IFN- γ and IL-2 production of CD8+ T cells specific for HBV.
