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It exerts its functions by binding and activating its receptor RANK [4], [5], which is expressed on the surface of osteoclastic precursors and mature osteoclasts [6].
RASSF1A lacks enzymatic activity and it exerts its functions mainly via interaction with and modulation of other molecules.
LPA is produced mainly by the enzyme autotaxin (lysophospholipase D), and it exerts its functions through the activation of one or more of at least six different receptors.
Interestingly, immune cells did not express receptors for IL-24 suggesting that this cytokine cannot stimulate immune reactions by directly interacting with cells from the immune system [2] but that it rather exerts its functions on keratinocytes, inflamed skin and/or yet unidentified target tissues.
It was reported that PPP3CA exerts its functions via interacting with integrins as well as heparan sulfate proteoglycan.
It seems likely that HESX1 exerts its functions not only through the interaction with TLE1 and N-CoR, but further interacting proteins, which remain to be characterised.
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It is known that the wild-type protein is resident in the nucleus where it exerts its function [16].
Results Clueless (Clu) is a large, highly conserved protein that is required for normal mitochondrial function; however, where it exerts its function is unclear.
It exerts its function through phosphorylation of its target substrates, such as p70 S6 kinase and 4E-BP1 (which regulate translation), and DAP1 (which inhibits induction of autophagy).
Sequentially, to further explore the molecular mechanisms by which miR-224 exerts its function, the determination of its functional target gene is essential.
It is not clear if vitamin B12 exerts its function only through its role as the co-factor of two enzymes mentioned above.
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