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All the above results indicate that the DNA repair pathway not only exerts functions directly on the active DNA demethylation but also maintains the progression of active DNA demethylation and repairs the active DNA demethylation-induced DNA damages.
If XBP1 exerts functions depending on IRE1α, splicing of XBP1 mRNA by IRE1α would be necessary.
XIAP also exerts functions besides interacting with Smac and caspases 9, 3 and 7.
mTOR exerts functions mainly by activating its downsteam targets S6RP and 4EBP1 that control mRNA translation and protein synthesis [ 2].
Given that Nur77 exerts functions within the osteoclast itself, we decided to investigate whether Nur77 affects RANKL signaling pathways.
The argument is that KAP1 exerts functions via recruitment of secondary modulators (HP1 etc).. This, to me, needs to be explored.
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Interestingly, there is also evidence that Frizzled receptors can exert functions independently of β-catenin.
Several of these proteins appear to exert functions in axomyelinic maintenance.
These findings are thus the first indication that chemokines can exert functions through pathways unrelated direct intercellular communication.
Sustained expression in RPE, photoreceptors and bipolar cells (BC) (Fig. S1) suggested that Otx2 gene could exert functions in the mature retina.
Recent studies suggest that lncRNAs may exert functions through targeting miRNAs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com