In summary, the transcription of DXS may be controlled by sterol levels, and sterol biosynthesis potentially exerts feedback regulation on isoprenoid biosynthesis, including cholesterogenesis.
Since we find that fusion of these vesicles precedes completion of autophagy and TORC1 activation, we hypothesize that by regulating the subcellular localization of TRPML, TORC1 exerts feedback control on autophagic flux (Fig. 1).
This study was designed to test a hypothesis that the CD38/cADPR pathway as a downstream event exerts feedback regulatory action on the NAD(P H oxidase activity in production of extra- or intracellular O2− in mouse coronary arterial myocytes (CAMs).
Data presented support our hypothesis that these trees exert feedback interactions on groundwater and sediment chemistry.
We also highlight examples of how biosensors can be integrated with synthetic circuits to exert feedback regulation on the metabolism for improved performance of cell factories.
We show that phosphatidylethanolamine, the major phospholipid inDrosophila, controls the release of sterol regulatory element binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids.
Although the subcellular compartmentation of this metabolite is unknown, it seems likely that cytosolic malate levels could be sufficient to exert feedback inhibition on the BTPC subunit of COS Class-2 PEPC.
This highlights the need to consider the possibility that ammonium exerts negative feedback on nitrate uptake by sugarcane.
Together, these results lead us to propose that: 1) the function of Fgf in blastema formation is, at least in part, relayed by the chemokine Sdf1a, and that 2) Sdf1 exerts negative feedback on the Fgf pathway, which contributes to a transient expression of Fgf20a downstream genes at the beginning of regeneration.
For example FOXO exerts positive feedback on its own synthesis [ 100], and there are additional mutual regulations of FOXO, Akt and PP2A [ 101, 102].
