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However, it exerts also a variety of non-specific, HO-1 independent effects [21], [22].
In contrast, the widely used atypical antipsychotic clozapine has a relatively poor affinity to D2 receptors, but exerts also antagonistic effects at histamine receptors, muscarinic acetylcholine receptors, α-adrenoceptors and serotonin receptors [3], [4].
However, malignant tumor evidently exerts also a general influence on the organism.
Previous studies demonstrated that ApoE exerts also pleiotropic antiatherosclerotic and anti-inflammatory cellular effects.
Aldosterone exerts also apoptotic responses mainly by mitochondrial-dependent mechanisms [ 9], and these effects are worsened in hyperlipidemia and obesity [ 1, 6].
However, the present study reveals that quercetin exerts also acute lipid-lowering effects such as reduced postprandial plasma TG and NEFA concentrations.
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A good influence was exerted also by the nitro and bromo substitution.
The obtained results appear to show that, in addition to neuroprotective action, FK506 and CsA can exert also antiepileptic influences.
Apart of its well characterized enzymatic activity, heparanase was noted to exert also enzymatic-independent functions.
LM-MP preparations exerted also a myogenic effect on ES-NS, although to a lesser extent.
Likewise, DMSO exerted also minor (~5%) but repeatable suppressive effect (not shown).
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