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The extent of the pain that shelter users experience exerts a considerable impact on their daily activities, with general activity and walking most affected.
PDE4 inhibition often substantially increases their PKA-dependent phosphorylation, and thereby exerts a considerable impact on the function of the associated signaling proteins in isolated cardiomyocytes in culture [ 11, 50, 65, 84], though the effects of acute PDE4 inhibition on cardiac performance in live animals are often subtle.
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Milk also exerted a considerable impact on healthcare provision.
As it is known to us, a considerable impact load induced at difference modes of vibration through earthquake and exerted on bracing components if the direction of forces change and components stretch under the influence of components' buckling caused by pressure (Ravi Kumar et al. 2007).
Such a step could have a considerable impact, analysts said.
This had a considerable impact on the play.
These can have a considerable impact on your business model.
"Even small wording changes could have a considerable impact".
This is a powerful testament, and one that ought to have a considerable impact.
This will have a considerable impact on the quality of people's lives.
As the largest English-language publisher, Random House has a considerable impact on the market for manuscripts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com