Sentence examples for exerting its role from inspiring English sources

SCF is a cytokine exerting its role through binding to c-kit receptor [ 13], which can be shed from the cell surface and is detected in the serum as soluble c-kit (sc-kit) [ 14].

SCF (stem cell factor) is a pleiotropic cytokine exerting its role at different stages of bone marrow development and affecting eosinophil activation, mast cells and basophil chemotaxis and survival.

This result suggests that NT-3 promotes neurite outgrowth in the cortical neuron, and knockdown of Dok6 partially blocks the NT-3 promotion effect in neurite outgrowth, which implies that Dok6 is exerting its role in cortex neuron neurite outgrowth through the NT-3/TrkC pathway.

Stem cell factor (SCF)- the c-kit ligand, although initially was described as a mast cell growth factor [ 1] appeared to be a pleiotropic cytokine exerting its role at the first stages of bone marrow stem cells development [ 2], inducing eosinophil activation [ 3] and basophil chemotaxis and survival [ 4].

Hence it is involved in the binding specificity of Ir-LBP and plays a key role in ligand binding as confirmed by mutational analysis (which also showed that it exerts its role in cooperation with Arg 53).

When SPARC is secreted from stroma cells, it exerts its role on neoplastic progression in a paracrine fashion (Porte et al, 1995; Le Bail et al, 1999).

Alternatively, it is possible that maspin exerts its role only in the nucleus at the level of gene or chromatin regulation and thus indirectly affects the cell-matrix interaction or differentiation state and is released only as a consequence of cell damage or necrosis [20 27].

Mutation of p21WAF1/CIP1 is rare in different types of human malignancy, therefore, it is suggested that p21WAF1/CIP1 exerts its role in tumorigenesis mainly on expression level.

It is possible that ETK may exert its role in bladder cancer through regulating these pathways.

NapA is directly activated by oxidation through ROS, allowing it to enter the nucleus and exert its role as a positive transcription factor.

In fact, it was observed in both animal models of bleomycin-induced fibrosis and in lung tissues of IPF patients that HIF 1- α is overexpressed and may exert its role in early stages of fibrogenesis as it was localized in areas of active fibrosis and in normal areas of IPF lung but not within the fibroblastic foci which represent areas of established fibrosis [ 42].