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Importantly, USP4 could bind to itself and also interact with USP11 and USP15, and thus may be part of a DUB complex when exerting its function (Zhang et al., 2012a; Zhang et al., 2012b).
These results suggest that SMILE might have a role in protein folding and/or degradation, exerting its function via the proteasome pathway.
Due to the detailed mechanism of Slit-Robo signaling exerting its function in gastric tumorigenesis is not clearly and fully understood.
It can be supposed that phosphorylated paxillin (i.e., activated paxillin exerting its function in cell adhesion) is located in the focal adhesion plaques, while in the cytosolic fraction, nonactive paxillin is not phosphorylated [ 44– 44].
All of the stages shown are from time points when isoform 2 is expressed at 10 fold lower levels as demonstrated in Figure 2. What about P0 or earlier, when isoform 2 is supposed to be exerting its function and important for development?
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Available information suggests that heparanase may function as a regulatory factor in different pathological conditions, including tumor and inflammation, exerting its functions through modification of HS structure [ 34].
It is known that the wild-type protein is resident in the nucleus where it exerts its function [16].
FoxP2 is a transcription factor, thus the mechanism by which it exerts its function(s) is through control of downstream genes.
Results Clueless (Clu) is a large, highly conserved protein that is required for normal mitochondrial function; however, where it exerts its function is unclear.
It exerts its function through phosphorylation of its target substrates, such as p70 S6 kinase and 4E-BP1 (which regulate translation), and DAP1 (which inhibits induction of autophagy).
6 It exerts its function at the beginning of the intrinsic apoptotic pathway and causes cell cycle arrest at G1 phase in response to DNA damage.
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