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Nonetheless, these results overall may be indicative of main effect SNPs exerting function in a tissue or cell type principal to that phenotype and the GxE SNP could be sensing differentials in environmental factors in other or peripheral tissues.
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Mitochondrial DNA (mtDNA) consists of 37 genes encoding 13 mitochondrial proteins exerting functions in the OXPHOS system [ 3].
MicroRNAs (miRNAs) that exert function by posttranscriptional suppression have recently brought insight in our understanding of the role of non-protein-coding RNAs in carcinogenesis and metastasis.
Candidate genes are those coding for proteins that have been described to exert function as "heterochromatin guardians".
As is well known, miRNAs exert function through suppressing the expression of their target genes.
Interestingly, there is also evidence that Frizzled receptors can exert functions independently of β-catenin.
Several of these proteins appear to exert functions in axomyelinic maintenance.
These findings are thus the first indication that chemokines can exert functions through pathways unrelated direct intercellular communication.
Sustained expression in RPE, photoreceptors and bipolar cells (BC) (Fig. S1) suggested that Otx2 gene could exert functions in the mature retina.
Recent studies suggest that lncRNAs may exert functions through targeting miRNAs.
Consequently, T1/ST2 may exert functions in addition to the transduction of IL-33-induced signals.
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