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We show that phosphatidylethanolamine, the major phospholipid inDrosophila, controls the release of sterol regulatory element binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids.
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Data presented support our hypothesis that these trees exert feedback interactions on groundwater and sediment chemistry.
We also highlight examples of how biosensors can be integrated with synthetic circuits to exert feedback regulation on the metabolism for improved performance of cell factories.
In summary, the transcription of DXS may be controlled by sterol levels, and sterol biosynthesis potentially exerts feedback regulation on isoprenoid biosynthesis, including cholesterogenesis.
Although the subcellular compartmentation of this metabolite is unknown, it seems likely that cytosolic malate levels could be sufficient to exert feedback inhibition on the BTPC subunit of COS Class-2 PEPC.
Similar adaptive mechanisms leading to cholesterol-ester accumulation exist when mice that are unable to exert feedback-inhibition by cellular cholesterol (i.e. Lxrα −/− mice) are challenged with dietary cholesterol [34].
OHCs are most effective at exerting electromechanical feedback to the cochlear partition at frequencies close to the characteristic frequency of their location on the BM.
Interestingly, both RB69pol and T4pol bind to their own mRNAs, specifically repressing translation, thus exerting tight feedback control on the level of DNA polymerase that is produced in the bacterial cell after phage infection.
These observations pointed to a direct effect of IL-6 on the hepatic expression levels of Socs3 under HFD feeding, thereby likely exerting a feedback inhibition of the IL-6-mediating signaling.
This study was designed to test a hypothesis that the CD38/cADPR pathway as a downstream event exerts feedback regulatory action on the NAD(P H oxidase activity in production of extra- or intracellular O2− in mouse coronary arterial myocytes (CAMs).
PKA exerts feedback on the system in several ways.
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