Sentence examples for exerting efficacy from inspiring English sources

More importantly, if KBU2046 were exerting efficacy by inhibiting phosphorylation of the Ser226 residue, then the presence of a phospho-mimic residue should, by definition, decrease additional efficacy.

Further, if KBU2046 were exerting efficacy by inhibiting phosphorylation of the Ser226 residue, then removal of that residue should, by definition, preclude additional efficacy.

Haloperidol, a typical antipsychotic, is non-selective and binds to a broad range of receptors, exerting efficacy mainly through the antagonism of dopamine receptors.

Bortezomib, a proteasome inhibitor, may exert efficacy in TNBC through its multiple cellular effects.

Since the inversion from R to S is lower in humans than in mice, it remains to be answered to what extent R-flurbiprofen may exert efficacy in multiple sclerosis.

Use of low GABA concentration allows detecting compounds exerting low efficacy modulation.

Thus, there is a continuing need for agents that exert efficacy equal to or greater than that achieved with TCAs and that have a more favorable side-effect profile (Class Ia, recommendation A [see Supplementary material]).

The finding that aspirin exerted chemopreventive efficacy when administered in utero and during weaning is consistent with these pharmacokinetic considerations, in that efficacy was probably the consequence of efficacious levels of salicylate in the mother's milk and the embryonic blood and tissues.

Rapamycin is a representative autophagy inducer that exerts its efficacy by inhibiting mTOR61, 62.

Robinson, G. W. et al. Vismodegib exerts targeted efficacy against recurrent sonic hedgehog-subgroup medulloblastoma: results from phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

XIE62-1004 and XIE2008 failed to induce the degradation of GFP-HDQ103 in ATG5 -/- MEFs (Fig. 6d), suggesting that these ligands exert their efficacy through autophagic induction.