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Moreover, miR-135a exerted this function through directly targeting very low density lipoprotein receptor (VLDLR), thus leading to the activation of the p38 MAPK pathway.
HOXA3 transcription factor may be required for the induction of pathogen-response genes in humans as it was shown that S. aureus infection induced a number of HOX genes that modulated the NF-κB -dependent transcription and exerted this function redundantly [ 61].
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Interestingly, it was shown that the C-terminal BRCT domains are also essential in exerting this function.
Some glycolytic enzymes (pyruvate kinase, phosphofructokinase, acetate kinase and phosphoglycerate kinase) have been shown to exert this function in M. genitalium, M. pneumoniae, M. fermentans and M. capricolum subsp. capricolum [46].
A literature-based meta-analysis disclosed that SPRR proteins do not only exert this function in squamous epithelia but also in a wide range of other major tissues and organs.
These results suggest that USP19 may lose its ability to regulate growth such as in the LNCaP cells or still exert this function through p27Kip1 as in a variety of other prostate cancer cell lines but this occurs through a pathway that bypasses the KPC1 ligase.
Tepoxalin and licofelone (ML3000) have been identified to exert this function [ 45, 46].
It exerts this function through two seemingly opposing and independent mechanisms (Fig. 6 ).
LTR alone does not exert this function and other viral genes could be involved [ 25].
This idea necessitates the existence of an 'active' path into latency in a population of neurons, and experimental data suggest LATs may indeed exert this function.
Taken together, these results indicate that ectopic ΔNp63 α expression inhibits cell invasion, and that both direct DNA binding and interaction with cellular proteins via the SAM domain are required for ΔNp63 α to exert this function.
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