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QD modified with polyethylene glycol-conjugated amine particles exerted robust inhibition on cell proliferation of J744A.1 macrophages, irrespective of apoptosis.
Both EDC and E2-BSA exerted robust neuroprotection in the CA1 against GCI, and the effect was blocked by the ER antagonist, ICI182,780.
Intriguingly, the cell impermeable E2 conjugates, EDC and E2-BSA both exerted robust neuroprotection against GCI, an effect that appeared to be mediated by ER, as pretreatment with the ER antagonist, ICI182,780 completely abolished the neuroprotective effect of both EDC and E2-BSA.
PKA phosphorylation exerted robust stimulation of currents mediated by homooligomeric GIRK4 channels.
Highly malignant MSDACs that were derived from metastatic sites exhibited CSC status and exerted robust tumorosphere formations ex vivo.
Accumulating evidences indicated that Nrf2 activation exerted robust protective effects against cytotoxicity caused by various injuries, suggesting that targeting the Nrf2 pathway could be a promising approach for therapeutic intervention of oxidative damage-related diseases, particularly neurodegenerative diseases.
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The agency's clandestine arm, its directorate of operations, was on Hayden's list of "muscular national collection agencies" over which the DNI needs to exert "robust authority". Hayden, who has rarely testified in public, was pressed by Sen. Dianne Feinstein (D-Calif). to give his views on why there was a failure in intelligence on Iraq's weapons programs before the U.S. invasion.
Similarity and relatedness exert robust effects on memory, with related or semantically similar items showing a recall and recognition advantage relative to unrelated items (e.g., Cofer, Bruce, & Reicher, 1966; Kintsch, 1968; Roediger & McDermott, 1995).
Rapamycin and other rapalogs have been shown to exert robust antineoplastic and oncopreventive effects in both transplantable and oncogene-driven tumor models.
Post-translational modifications to the α subunit, including phosphorylation and palmitoylation, can exert robust and rapid changes in channel function, effects that are isoform dependent.
Given the promising preclinical results, the failure of the TRAs that have thus far been tested clinically to exert robust anticancer activity in patients is disappointing.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com