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Some combination approaches have achieved enhanced antitumor effects in animal models and human clinical studies, 29, 30, 31 in which monotherapy has exerted only modest effects.
Therefore, it is maybe not surprising that exendin-4 exerted only modest effects on post-MI cardiomyocyte remodelling, which may have occurred directly or secondary to more pronounced effects on the ECM.
Whilst hypoxia exerted only modest effects on the production of mature miRNAs, we did see a significant influence of hypoxia on the operation of an exogenously introduced precursor miRNA.
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Finally, the strategies chosen to accomplish behavior change are known to generally exert only modest effects on clinicians' behavior.
Many of the newly developed targeted drugs will exert only modest activity when applied alone and will be more effective when combined with other drugs.
While 3′-methoxy-GTP exerted only a modest stimulatory effect (2-fold) on the rate of the reaction, no stimulation was observed with either 3′-dGTP or 2′3′-ddGTP.
In the case of sample recovery, this component has been demonstrated to exert only a modest effect [ 16, 27], which was confirmed in the present study using spiked healthy volunteer blood samples.
Because lopinavir/ritonavir and nevirapine are used in both strategies (as either first-line or second-line ART), variations in drug costs exert only a modest impact on the economically preferred strategy (panels B and C).
Furthermore, whereas the normalization of a single metabolic parameter, such as vitamin D3, may exert only a modest effect on pathogenesis, the optimization of a comprehensive set of parameters, which together form a functional network, may have a much more significant effect on pathogenesis and thus on function.
Occlusal force was exerted only on anterior teeth.
Common variants, yet unidentified, exert only small effects on risk.
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