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Calpain inhibition also amplified the Haelan-induced apoptotic activity in all cancer cell lines, but exerted no further effect in fibroblasts.
In TO cells, TG treatment exerted no further activation on the ER stress transducers; instead, it swayed the cells towards apoptosis.
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It is evident that in the double-mutants the chemical nature of the side-chain residue in position 823 exerts no further functional influence, presumably because of the major distortion already caused by the proline substitution in position 824.
CR exerts no further effect on the Sirt1 KO strain, suggesting the effects of CR and Sirt1 deletion are mechanistically coupled.
Thus, it may be useful for future research to investigate additional, theoretically relevant variables in this context to determine if they exert any further explanatory power.
It is worth mentioning that an increase in the dose of flagellin to 5 μg/mouse did not exert any further increase in the activation of MAPKs and NFκB, as shown by a comparable degree of ERK and IκBα phosphorylation in the different organs, suggesting that minute doses of flagellin are already sufficient to produce a maximal activation of these stress signaling cascades.
Variations in CA size and type were observed to exert no effects on BR, which further validated the adopted mesoscale current conduction model, and further indicated that interfacial transition zones do not exert a substantial influence on concrete resistivity.
While in France in 1905, he worked with the Fauvist painter Henri Matisse, whose flat areas of vibrant colour exerted a further influence on his work.
In order to further improve the immigration of photo-induced charge carriers during excitation state, considerable effort has to be exerted to further improve the heterogeneous photocatalysis under UV/visible/solar illumination.
In order to further improve the immigration of photo-induced charge carriers during excitation state, considerable efforts have to be exerted to further improve the charge mobility and maximize the dye loading.
The introduction of subsidies for maize grain imports and for the sale of maize flour products exerted a further downward pressure on prices.
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