Also in rice, a single locus (QTLGhd7) was recently identified on chromosome 7 and confirmed to simultaneously exert major effects on three classes of agriculturally important traits including grain number, plant height, and heading date [81].
Whereas even 10 µM CsA did not exert major effects on CCL19 production in human moDC, addition of 100 nM SFA one hour later markedly inhibited CCL19 expression (Figure 5A).
Bone cells exert major effects on the immune system.
Here, we show that the nature of both the linker and the fluorophore can exert major effects on the pharmacological properties of both agonists and antagonists.
However, a subsequent study reported that whereas flecainide prevented isoproterenol-induced CPVT, it did not exert major effects on Ca2+ homeostasis in RyR2-R4496C hearts (Liu et al. 2011).
Recently, it is appreciated that ECM molecules that lie between cells, in addition to providing a constructive framework, they exert major effects on cellular function.
Over-expression of RARα does not exert major effects on the basal growth rate of the MDA-MB-453 clones (Fig 10B).
In particular, under this scenario, genetic diversity within a population is protected from genome-wide selective sweeps that could potentially exert major effects on ecological characteristics of populations such as primary productivity [ 15].
For example, polymorphisms in pleiomorphic adenoma gene 1 (PLAG1) [ 1- 3], non-SMC condensin I complex, subunit G (NCAPG) [ 4- 6], and myostatin (GDF8, also known as MSTN) [ 7, 8] were found to exert major effects on stature, postnatal growth and muscle development, respectively.
The ryanodine and BAPTA-AM concentrations were such that Cai2+ transients were largely, but not fully, inhibited, whereas the cesium and tertiapin concentrations were selected to maximally inhibit If and IK,ACh, respectively, without exerting major effects on other membrane currents.
