It is known that the wild-type protein is resident in the nucleus where it exerts its function [16].
FoxP2 is a transcription factor, thus the mechanism by which it exerts its function(s) is through control of downstream genes.
Results Clueless (Clu) is a large, highly conserved protein that is required for normal mitochondrial function; however, where it exerts its function is unclear.
It exerts its function through phosphorylation of its target substrates, such as p70 S6 kinase and 4E-BP1 (which regulate translation), and DAP1 (which inhibits induction of autophagy).
Sequentially, to further explore the molecular mechanisms by which miR-224 exerts its function, the determination of its functional target gene is essential.
Therefore, Vpr is present during early stages of infection and available to rapidly exert its function on the cells it first encounters, DC of the mucosal membranes.
M-CSF exerts its function on osteoclasts where it induces differentiation and activates bone resorption with consequent increase of serum calcium levels.
It is not clear if vitamin B12 exerts its function only through its role as the co-factor of two enzymes mentioned above.
It is produced mainly in the liver and exerts its function by binding to the iron export protein, ferroportin, inducing its internalization and degradation [ 10].
