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Compounds 2b, 2c, 2f, 3e, and 3f exerted high selectivity towards cancer cell lines than L132 normal lung cells.
In vitro, the DOX-loaded micelles exerted high cytotoxicity in the DOX-resistant cells by bypassing MDR efflux.
Pluronic polymer-based micelles, to which folic acid (FA), redox-sensitive thiol groups and the anti-cancer drug doxorubicin (DOX) are chemically conjugated with pH-sensitive linkers, could be successfully delivered into multidrug-resistant (MDR) tumors in mice and exerted high cytotoxicity in the DOX-resistant MDR tumors by bypassing MDR efflux [57].
Fe-SP, at 3 µM, exerted high cytotoxic effects on all cells except SH-SY5Y.
Quercitrin exerted high inhibitory effect against xanthine oxidase activity, but not lipo-oxygenase activity (Table 5).> -wrap-foot> All values are expressed as mean ± SEM.
Asp-DOX exerted high inhibition on the uptake of L-leucine and its IC50 to L-leucine was determined to be approximately 30.12 μmol/L.
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Finally, fibroblasts exerted higher mobility than keratinocytes.
Our results revealed that nSP exerted higher cytotoxicity in macrophage cells compared with submicron-sized silica particles.
The results proved that, although SFC consumed shorter gelation time, yet SFL exerted higher antibiotic activity against the tested microorganisms.
Hence, soil internal forces exerted higher contribution to rainfall splash erosion than raindrop impact force under most field conditions.
Most quinones (33 36 and 38 43) exerted higher anticancer activity against HepG2 cell than that of the etoposide.
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