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The majority of approaches that deal with analysis of trajectories are focused on characterizing agents' dynamics through time [19 21] or learning interactive forces exerted by multiple moving agents.
We suggest that its variable frequency in different taxa results from the complex selective pressures exerted by multiple and different retroviral challenges.
We observe a statistically significant inverse correlation between BRCA1 and miR-146 (p = 0.05), but not between IRAK1 and miR-146, which suggests that IRAK1 gene regulation is probably complex and exerted by multiple factors upon different layers.
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A possible explanation could reside in the multiple actions exerted by Pax7, which not only is required to promote the proliferation of undifferentiated cells, but is also necessary for the myogenic differentiation to proceed [53].
Promising therapeutic effect and protection against SSG-unresponsive L. donovani infection can be attributed to multiple driving forces exerted by the combined activity of SSG and PC-SA leading to enhanced accumulation of SSG within parasites, direct killing of parasites induced by PC-SA and the switch of immunosuppressive humoral and cell-mediated responses to a protective Th1 type.
This explains in part the multiple target efficacy exerted by plant-based products.
Among the multiple antitumor activities exerted by trastuzumab on HER2-overexpressing breast cancer cells, inhibition of cell proliferation is reported to occur primarily by modulation of the cyclin-dependent kinase inhibitor p27Kp1, via a complex network of signalling pathways, resulting in G1 arrest and growth inhibition [ 61].
Whether produced by multiple sclerosis or chronic compression exerted by a blood vessel or a benign tumour, demyelination increases the susceptibility of the nerve fibres to ectopic excitation, ephaptic transmission, and high-frequency discharges.
In multiple analysis, the effect exerted by early relapses remained unchanged.
Many of the signalling complexes discussed above are assembled via non-catalytic kinase functions, but involve multiple positive feedback loops exerted by phosphorylation.
This might be a reflection of the multiple, additive layers of regulation exerted by ORCA on the process of preRC assembly and heterochromatin organization.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com