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In the presence of cGKII the cGMP-mediated shift was reduced to about 4 mV (Fig. 4B, and Fig. 4H, third and fourth column) suggesting that cGKII counteracted the stimulatory effect exerted by direct binding of cGMP to the channel CNBD.
However, whether the efficacy of QSYQ is exerted by direct inhibition of myocardial apoptosis or anti-inflammatory response remains to be validated.
On the one hand, this influence could be exerted by direct diminishment in the deacetylation level within the nucleosomal core-derived histone lysine moieties that was evoked by trichostatin A-mediated nonspecific inhibition of HDACs.
Similar(57)
It has been suggested that the negative regulatory effects of HilE are exerted by its direct interaction with HilD, such that HilD-mediated activation of hilA is prevented [20].
The virucidal assay rules out the possibility that the antiviral activity of the extract is exerted by a direct inactivation of the virus particle.
However, since diabetes mellitus itself is a risk factor for cancer, treatment of diabetes mellitus may reduce the risk; therefore, it is still unclear whether the suppressive effect of metformin against CRC may be exerted by the direct chemopreventive effect of the drug or be mediated by its antidiabetic effect.
Various types of blading arrangements have been proposed, but all are designed to take advantage of the principle that when a given mass of steam suddenly changes its velocity, a force is then exerted by the mass in direct proportion to the rate of change of velocity.
This dynamic stability relies on balancing counteracting forces: an apically directed force exerted by F-actin/myosin-2 via active cortical flow and a basally directed force mediated by microtubules and myosin-10.
Proponents of this view often refer to the close intertwining of Japanese industrial expansion and the direct influence exerted by Japanese investment in Australia, notably in the mining of coal and iron ore.
In this step, the decision-makers are required to evaluate the direct influence exerted by one attribute on another.
This interplay is positive because the negative direct impact exerted by advertising on welfare is outweighed by the positive effect associated with the fact the publicly owned platform's advertising increases the size of the private platform audience, which is socially profitable if the quality differential of the publicly owned platform is small (compared with (k)).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com