One mechanism that could underlie the enhancing effect of MnSOD siRNA on the cytotoxic chemotherapeutic agents is the reduction in the cellular capacity to withstand the oxidative damage exerted by these agents.
This parameter describes the proportion of hosts initially infected with wild-type virus who, as a result of within-host selective pressure exerted by antiviral agents, become predominantly infected with, and transmit, resistant viruses.
Empiric antimicrobial selection for critical care infections must balance the need for timely adequate coverage with the resistance pressure exerted by broadspectrum agents.
The reported changes in the tCho profile in cancer lesions are often associated with the cytotoxic effects exerted by chemotherapeutic agents.
The effects exerted by crosslinkable agent amount (DVB) and irradiation time are examined.
Moreover, the tumor stroma can 'protect' cancer cells from the cytotoxic insults exerted by anticancer agent, thus conferring therapeutic resistance.
Conversely, we observed that sequential exposure produced a greater cytotoxic effect than that exerted by single-agent use or simultaneous exposure.
If we accept (i) and (ii), then we must accept that some counterfactual features of the agent are relevant to the moral worth of the agent's actual action, and if we accept this it is difficult to see why the counterfactual effort exerted by the agent could not also be relevant.
The majority of approaches that deal with analysis of trajectories are focused on characterizing agents' dynamics through time [19 21] or learning interactive forces exerted by multiple moving agents.
As shown in Figure 6b, although the inhibitory effects exerted by the individual agents were mild, total and phosphorylated Akt and p38 were downregulated among the mice that received the combination treatment.
