Sentence examples for exerted at multiple from inspiring English sources

Here we show that delayed treatment with a novel PARP-1 inhibitor has great benefit at the clinical and pathological levels, as its therapeutic action was exerted at multiple levels, being associated with the downregulation of inflammatory and Th1-mediated autoimmune components of the disease.

The tumor-driving potential of mutant p53 is exerted at multiple levels: dampening oncosuppressive pathways (p63 and other growth suppressors); enhancing multiple oncogenic pathways relevant in breast cancer (such as PI3K/AKT, Ras/mitogen-activated protein kinase (MAPK) and NF-κB) both directly and indirectly; and altering the cellular physiology at posttranscriptional level via non-coding RNAs.

Together, they can exert pressure at multiple points on individuals much less vulnerable than Rohith Vemula.

The skeletal site-specific influence of multiple genes on bone morphology is recognised, but the question as to how these influences may be exerted at the molecular and cellular level has not been explored.

The distal distraction was exerted at the distal phalanx.

Maximum action is exerted at S phase, but toxicity is usually exerted in G2 phase.

In addition to these breast tumor-specific alterations, it is possible that Myc is deregulated in most breast tumors since the normal tight control that is exerted on Myc at multiple levels is impaired in essentially all cancer cells.

Powell et al. also argued that the CFIR suggests implicitly that "successful implementation may necessitate the use of an array of strategies that exert their effects at multiple levels of the implementation concept" ([ 7], p. 194).

Taking all factors into consideration, we conclude that translation selection is exerted on genome sequences at multiple levels and by various mechanisms.

Desmin exerts its multiple functions through direct and indirect binding to various other cellular molecules.

HPr-S46 phosphorylation affects cell metabolism at multiple levels exerting its effect through CCR, inducer exclusion, as well as phosphorylation of transcription regulators and several metabolic enzymes [ 47].