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It had steric hindrance on the 150 cavity of N1 protein, and exerted activities across the H274Y and N294S mutations.
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Previous data established that plitidepsin, a cyclic depsipeptide, exerted activity in a mouse model of myelofibrosis (MF).
Many complementary and alternative medicine (CAM) approaches and interventions are thought to exert activities by enhancing immune function.
The novel benzopyran compound tonabersat is a unique molecule, which has been demonstrated to exert activity as a gap-junction inhibitor in animal studies.
The CBDs exerts activity that can be utilized for effective degradation of crystalline cellulose, plant cell wall relaxation, expansion and cell wall biosynthesis.
Considering transmembrane topology, TM-PLDs might exert activity against substrates or targets within the organelle (luminal side), but not on the cytoplasmic side.
This may suggest additional situations in vivo in which PAP derived peptides could exert activity in the absence of fully elongated amyloid fibrils.
Sunitinib is well-known as an inhibitor of angiogenesis and to exert activity against VEGFR2.
It exerts activity of carbonic anhydrase and capacity of binding to cell surface receptors.
In the field of photodynamic therapy, several photosensitizers have been shown to exert activity through their accumulation in lysosomes.
22, 30 We were unable to block patient antibody-mediated NMDAR internalization with APV, suggesting that patient antibodies did not exert activity-dependent effects.
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